I had 22" rims for about a month and here's my 2 cents:
In regards to overall appearance, there's no question. 22's looks awesome! But that's really it. The ride was rougher, and I had to change my driving habits because I felt I had to be super careful in order to make sure I don't damage them. You can feel how much heavier they are in both acceleration and breaking. I just sold my 22's a few days ago and I'm planning on gettin 20's.